Figure 5.

Ly-49D expression in BALB/c NK cells confers cytotoxic capacity against CHO targets. (A) IL-2-activated BALB/c NK cells that were uninfected or infected with 50 pfu per cell of either wild-type vaccinia WR strain or a recombinant Ly-49D–vaccinia virus were analyzed for Ly-49D expression by using mAb 4E4. (B) The NK cell populations shown in A, as well as uninfected B6 NK cells, were assessed for their capacity to lyse CHO targets alone or in the presence of either 4E4 or an isotype-matched control mAb, mouse anti-rat Ig. YAC-l lysis is shown for comparison and was unaltered. Data shown represent lysis at E:T of 10:1.