Table 1.
Measurements at intervals after injury
| Time after injury (hours) | ||||||
| BL | 3 | 6 | 12 | 18 | 24 | |
| Body temperature (°C) | ||||||
| Control | 39.1 ± 0.16 | 39.6 ± 0.19 | 39.5 ± 0.12 | 39.5 ± 0.11 | 39.7 ± 0.27 | 39.9 ± 0.17 |
| MRSA sepsis | 39.2 ± 0.11 | 40.9 ± 0.13† | 41.0 ± 0.08† | 40.3 ± 0.11† | 40.1 ± 0.22 | 40.5 ± 0.29 |
| CVP (mmHg) | ||||||
| Control | 7.2 ± 0.8 | 10.8 ± 0.5 | 11.5 ± 1.1 | 10.2 ± 1.5 | 9.5 ± 0.6 | 8.8 ± 0.6 |
| MRSA sepsis | 5.5 ± 0.9 | 7.6 ± 1.4 | 8.0 ± 1.5 | 11.1 ± 1.2 | 16.7 ± 2.3† | 14.5 ± 2.4 |
| MPAP (mmHg) | ||||||
| Control | 20.2 ± 0.7 | 25.3 ± 1.4 | 27.0 ± 0.9 | 27.0 ± 2.0 | 26.7 ± 1.9 | 25.8 ± 1.8 |
| MRSA sepsis | 19.6 ± 0.4 | 23.4 ± 0.7 | 28.4 ± 1.6 | 30.0 ± 1.5 | 34.5 ± 1.4† | 32.8 ± 2.1† |
| Pc (mmHg) | ||||||
| Control | 12.9 ± 0.9 | 17.1 ± 0.8 | 17.8 ± 0.5 | 17.4 ± 1.6 | 17.4 ± 1.3 | 16.7 ± 1.2 |
| MRSA sepsis | 12.4 ± 0.5 | 13.5 ± 0.6 | 15.8 ± 1.0 | 19.6 ± 0.8 | 23.5 ± 1.3† | 22.4 ± 1.9† |
| PL-tot (mg/hour) | ||||||
| Control | 147 ± 30 | 117 ± 27 | 147 ± 30 | 211 ± 65 | 228 ± 78 | 267 ± 74 |
| MRSA sepsis | 122 ± 38 | 539 ± 115† | 728 ± 124† | 636 ± 140† | 610 ± 105† | 611 ± 198 |
| CI (mL/min-1/m-2) | ||||||
| Control | 5.8 ± 0.2 | 5.5 ± 0.2 | 6.0 ± 0.8 | 5.3 ± 0.6 | 5.3 ± 0.4 | 4.9 ± 0.4 |
| MRSA sepsis | 6.2 ± 0.3 | 7.0 ± 0.4 | 6.7 ± 0.4 | 8.1 ± 0.5† | 10.2 ± 0.9† | 9.2 ± 0.8† |
| HR (bpm) | ||||||
| Control | 94 ± 1.9 | 110 ± 3 | 116 ± 4.9 | 107 ± 6.2 | 104 ± 6.2 | 103 ± 5.9 |
| MRSA sepsis | 95 ± 4.1 | 155 ± 11.5† | 162 ± 7† | 167 ± 7.4† | 156 ± 7.6† | 142 ± 15† |
| PaO2/FiO2 ratio | ||||||
| Control | 509 ± 15 | 482 ± 35 | 519 ± 16 | 501 ± 20 | 532 ± 32 | 521 ± 12 |
| MRSA sepsis | 504 ± 7 | 287 ± 24† | 304 ± 27† | 215 ± 27† | 156 ± 23† | 123 ± 26† |
| Qs/Qt | ||||||
| Control | 0.15 ± 0.01 | 0.19 ± 0.01 | 0.17 ± 0.02 | 0.2 ± 0.03 | 0.19 ± 0.02 | 0.18 ± 0.01 |
| MRSA Sepsis | 0.16 ± 0.01 | 0.31 ± 0.01† | 0.28 ± 0.02† | 0.38 ± 0.03† | 0.44 ± 0.03† | 0.49 ± 0.05† |
All data are shown in control and methicillin-resistant Staphylococcus aureus (MRSA) sepsis groups. Data are expressed as mean ± standard error of the mean. † p < 0.05 versus control.
BL = baseline; CI = cardiac index; CVP = central venous pressure; HR = heart rate; FiO2 = fraction of inspiratory oxygen; MPAP = mean pulmonary artery pressure; PaO2 = partial arterial pressure of oxygen; Pc = pulmonary capillary pressure; PL-tot = total lung lymph protein; Qs/Qt = pulmonary shunt fraction.