Table 2.
Clinical outcomes according to treatment group
| Control group (n = 27) |
Decremental PEEP titration group (n = 30) |
p value | |
| Responder (%) | 44.4 | 70 | 0.046 |
| Clinical outcomes | |||
| Duration of mechanical ventilation, days | 15.2 ± 3.2 | 19.8 ± 0.5 | 0.380 |
| Intensive care unit stay, days | 21.4 ± 5.3 | 25.1 ± 5.6 | 0.643 |
| Duration of paralysing agent, days | 9.0 ± 2.3 | 11.8 ± 2.0 | 0.358 |
| Duration of sedative agents, days | 14.2 ± 2.4 | 18.7 ± 3.4 | 0.303 |
| Weaning trial within seven days | 8 | 6 | |
| Tracheostomy | 5 | 8 | |
| Reintubation | 5 | 2 | |
| Barotrauma | 3 | 3 | |
| Ventilator-associated pneumonia | 5 | 5 | |
| Mortality, number (%) | |||
| Mortality at 28 days | 9 (33.3) | 12 (40) | 0.784 |
| Death in the intensive care unit | 13 (48.1) | 14 (46.7) | 1.000 |
| Mortality at 60 days | 15 (55.6) | 14 (46.7) | 0.599 |
| Cause of in-hospital death, number (%) | |||
| Progressive respiratory failure | 8 (53.3) | 8 (57.1) | |
| Refractory septic shock | 4 (26.7) | 2 (14.3) | |
| Hepatic failure | 3 (20) | 2 (14.3) | |
| Myocardial infarction | 2 (14.3) | ||
| Rescue therapy (%) | |||
| Prone position | 44.4 | 50.0 | 0.792 |
| Nitric oxide inhalation | 48.1 | 53.3 | 0.793 |
Data was presented as mean ± standard error of the mean. PEEP = positive end-expiratory pressure.