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. 2009 Mar 29;11(2):R48. doi: 10.1186/ar2661

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Copyright © 2009 Lee et al.; licensee BioMed Central Ltd.

This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Activation of extracellular-regulated kinase (ERK1/2) and nuclear factor κB (NFκB) following infection of synovial fibroblasts with Candida albicans. (a) Synovial fibroblasts were infected for 12 h with C. albicans and levels of total and phosphorylated ERK1/2 (P-ERK1/2) assessed. Tubulin served as protein loading control. Shown is a representative western blot from one of five experiments. (b) Synovial fibroblasts were infected for 6 h with C. albicans and NFκB activation assessed by electrophoretic-mobility shift assay (EMSA). Upper panel: NFκB EMSA. The first lane of the NFκB series is the blank control. The lower series is the cold control. Lower panel: semiquantitative analysis of EMSA band density (N = 3, *P < 0.05).