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. 2009 Mar 29;11(2):R48. doi: 10.1186/ar2661

Figure 4.

Figure 4

Immunocytochemical detection of cyclo-oxygenase 2 (COX-2) and phospho-extracellular-regulated kinase (ERK)1/2 expression in synovial fibroblasts infected with Candida albicans for 12 h. Synovial fibroblasts infected with C. albicans in the absence (c) or presence (d) of the mitogen-activated protein kinase (MEK)1/2 inhibitor U0126 were immunostained for COX-2 and phosphorylated ERK1/2. (a) Negative control with omitted primary antibody. (b) Control synovial fibroblasts. (c) Synovial fibroblasts infected with C. albicans. (d) Synovial fibroblasts infected with C. albicans in the presence of U0126 (insert × 1,000; others × 400).