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. 1999 May 25;96(11):6336–6340. doi: 10.1073/pnas.96.11.6336

Figure 2.

Figure 2

NK cell development is blocked by treatment of mice with LTβR–Ig. Pregnant mice at gestational day 16 were treated with LTβR–Ig (25 μg) i.p., and each offspring was treated again on day 7 after birth. Splenocytes collected at day 28 after birth were stained for expression of NK1.1. (Lower) Splenocytes from mice treated with LTβR–Ig. (Upper) Control C57BL/6J mice treated with 25 μg of human LFA-1–Ig fusion protein and C57BL/6-RAG-1−/− mice treated with 25 μg of mouse total IgG. (Left) Data from C57BL/6J splenocytes. (Right) Data for C57BL/6-RAG-1−/− splenocytes. Similar data were obtained in four additional experiments with a range of NK cell reduction from 40–80%.