Table 1.
Immunohistochemical analysis of synovial tissue biopsies from early untreated Behçet disease and psoriatic arthritis
| Behçet disease | Psoriatic arthritis | P value | |||
| n = 8 | n = 9 | ||||
| Synovial immunopathology (cells/mm2) | |||||
| CD68 lining | 3,681 | (877–6,831) | 2,947 | (541–4,834) | NS |
| CD68 sublining | 529 | (311–2,339) | 739 | (183–2,636) | NS |
| CD3 | 1,077 | (354–1,427) | 336 | (164–1,036) | 0.015 |
| CD4 | 516 | (31–1,306) | 196 | (3–1,061) | NS |
| CD8 | 524 | (2–832) | 113 | (3–669) | NS |
| CD20 | 126.5 | (61–703) | 106 | (38–510) | NS |
| Lymphoid aggregates | 0.93 | (0.34–6.8) | 0.43 | (0–3.04) | NS |
| Grade-3 lymphoid aggregates | 0.08 | (0–1.38) | 0 | (0–0.44) | NS |
| CD138 | 45 | (11–432) | 173 | (8–1,490) | 0.071 |
| CD56 | 17 | (1–144) | 9 | (2–77) | NS |
| Granzyme B | 12 | (2–93) | 9 | (2–20) | NS |
| Perforin | 8.5 | (3–26) | 6 | (1–22) | NS |
| CD15 lining | 919 | (101–4,436) | 275 | (11–1,015) | 0.036 |
| CD15 sublining | 305.5 | (31–1,050) | 203 | (25–467) | NS |
| CD117 | 60 | (21–286) | 162 | (29–365) | 0.046 |
| CD31 (vessels/mm2) | 80 | (60–255) | 133 | (63–166) | NS |
After immunostaining of paraffin or frozen sections, the number of positive cells per square millimeter was assessed by digital image analysis. Data are presented as median (range). NS, non-significant.