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The presence of different anti-PM/Scl antibodies depends on the underlying disease subset in systemic sclerosis (SSc). Co-occurrence of antibodies that recognize different recombinant antigens as detected by line immunoblot assay in all anti-PM/Scl-positive patients (a), in patients with diffuse SSc (dSSc) (b), in patients with limited SSc (lSSc) (c), and in patients with overlap syndromes (d). anti-topo I, anti-topoisomerase I; CENP-B, centromere protein-B; PM, polymyositis.
