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Cumulative survival from time of diagnosis related to the presence of anti-topoisomerase I antibodies. Cumulative survival rates from the time of diagnosis related to the presence of anti-topoisomerase I antibodies (anti-topo I ab) in our cohort of 96 patients with diffuse systemic sclerosis (SSc) as detected by line immunoblot assay (LIA). Signal strengths above 150 units were associated with increased mortality (P = 0.003).
