Table 2.

For the suicide prevention (“prevention”) and therapy (“therapy”) studies, ITT, standard regression, and SMM estimates are presented for the direct effects of the randomized baseline intervention (care manager or CBT) and the mediator (anti-depressant medication or adjuvant therapy). Standard errors and nominal 95% confidence intervals are in parentheses.

Suicide Study	Method	Direct Effect	Mediator Effect
Prevention	ITT	−3.12 (0.82) (−4.72, −1.51)
	Standard	−2.67 (0.89) (−4.41, − 0.93)	−1.19 (0.94) (−3.03, 0.65)
	SMM	−2.58 (1.27) (−5.07, −0.10)	−1.43 (2.34) (−6.01, 3.15)
Therapy	ITT	−6.35 (2.53) (−11.37, − 1.33)
	Standard	−6.86 (2.60) (−12.01, −1.70)	−3.05 (3.46) (−9.92, 3.82)
	SMM	−3.93 (3.09) (−9.98, 2.12)	14.59 (15.87) (−16.52, 45.69)