Table 2.
List of proteins identified with 99% and 95% confidence in human saliva.
| Protein name | Accession nr | Function | Mass (Da) |
|---|---|---|---|
| 99% confidence: | |||
| 14-3-3 protein beta/alpha | P31946 | Signalling | 27951 |
| 14-3-3 protein zeta/delta§ | P63104 | Signalling | 27745 |
| 6-phosphogluconate dehydrogenase, decarboxylating | P52209 | Energy/metabolism | 53009 |
| 78 kDa glucose-regulated protein precursor§ | P11021 | Protein Folding/Repair | 72333 |
| Actin§ | P60709 | Structural/Cytoskeletal | 41737 |
| Actin-like protein 3# | P61158 | Structural/Cytoskeletal | 47240 |
| Actin-related protein 2/3 complex subunit 4# | P59998 | Structural/Cytoskeletal | 19536 |
| Adenine phosphoribosyltransferase | P07741 | Energy/metabolism | 19477 |
| Adenosylhomocysteinase# | P23526 | Energy/metabolism | 47585 |
| Alcohol dehydrogenase [NADP+]# | P14550 | Energy/metabolism | 36442 |
| Alcohol dehydrogenase class IV mu/sigma chain# | P40394 | Energy/metabolism | 40006 |
| Aldehyde dehydrogenase, dimeric NADP-preferring# | P30838 | Energy/metabolism | 50379 |
| Aldo-keto reductase family1 member B10 | O60218 | Energy/metabolism | 36021 |
| Alpha enolase§ | P06733 | Energy/metabolism | 47038 |
| Alpha-1-acid glycoprotein 1 precursor§,# | P02763 | Defense/Immunoresponse | 23512 |
| Alpha-1-antitrypsin precursor§ | P01009 | Protein Degradation/Inhibitor | 46737 |
| Alpha-actinin 1§ | P12814 | Structural/Cytoskeletal | 103058 |
| Apolipoprotein A-I precursor§ | P02647 | Transport | 30778 |
| Arginase 1§ | P05089 | Energy/metabolism | 34735 |
| ATPase 4, plasma membrane-type# | Q9SU58 | Micro organism | 105718 |
| Bactericidal permeability-increasing protein precursor# | P17213 | Transport | 53396 |
| Calgranulin B§ | P06702 | Cell Adhesion/Communication | 13242 |
| Carbonic anhydrase VI precursor§ | P23280 | Energy/metabolism | 35365 |
| Carboxylesterase 2 precursor | O00748 | Energy/metabolism | 61807 |
| Cathepsin D precursor | P07339 | Protein Degradation/Inhibitor | 44552 |
| Ceruloplasmin precursor§ | P00450 | Transport | 122205 |
| Chaperone protein dnaK# | Q7NXI3 | Micro organism | 69122 |
| Chitinase 3-like protein 2 precursor# | Q15782 | Cell Growth/Differentiation | 43501 |
| Chloride intracellular channel protein 1 | O00299 | Transport | 26792 |
| Clusterin precursor§ | P10909 | Cell Growth/Differentiation | 52495 |
| Cofilin, non-muscle isoform | P23528 | Structural/Cytoskeletal | 18371 |
| Complement C3 precursor§ | P01024 | Signalling | 187164 |
| Complement C4 precursor§ | P01028 | Defense/Immunoresponse | 192771 |
| Complement factor H precursor§,# | P08603 | Energy/metabolism | 139070 |
| Coronin-1A | P31146 | Structural/Cytoskeletal | 50895 |
| Cystatin A§ | P01040 | Protein Degradation/Inhibitor | 11006 |
| Cystatin B§ | P04080 | Protein Degradation/Inhibitor | 11140 |
| Cystatin C precursor§ | P01034 | Protein Degradation/Inhibitor | 15799 |
| Cystatin D precursor | P28325 | Protein Degradation/Inhibitor | 16080 |
| Cystatin S precursor | P01036 | Protein Degradation/Inhibitor | 16214 |
| Cystatin SA precursor | P09228 | Protein Degradation/Inhibitor | 16445 |
| Cystatin SN precursor | P01037 | Protein Degradation/Inhibitor | 16362 |
| Dermcidin precursor§,# | P81605 | Defense/Immunoresponse | 11284 |
| Desmocollin-2 precursor | Q02487 | Cell Adhesion/Communication | 99962 |
| Desmoglein-3 precursor | P32926 | Cell Adhesion/Communication | 107503 |
| Diablo homolog, mitochondrial precursor# | Q9NR28 | Signalling | 27131 |
| Dihydroxy-acid dehydratase# | Q8XWR1 | Micro organism | 58965 |
| Dipeptidyl peptidase IV§,# | P27487 | Protein Degradation/Inhibitor | 88279 |
| DNA polymerase IV# | Q9JYS8 | Micro organism | 35966 |
| Elongation factor 1-alpha§ | P68104 | Protein Synthesis | 50141 |
| Elongation factor 1-gamma | P26641 | Protein Synthesis | 49988 |
| Ezrin§,# | P15311 | Cell Growth/Differentiation | 69268 |
| F-actin capping protein beta subunit | P47756 | Structural/Cytoskeletal | 31219 |
| Farnesyl pyrophosphate synthetase# | P14324 | Energy/metabolism | 40532 |
| Fatty acid-binding protein, epidermal | Q01469 | Energy/metabolism | 15033 |
| Fibrinogen gamma chain precursor§ | P02679 | Protein Modification/Polymerization | 51512 |
| FixC protein# | Q8Z9K9 | Micro organism | 45687 |
| Fructose-bisphosphate aldolase A§ | P04075 | Energy/metabolism | 39289 |
| Fructose-bisphosphate aldolase C | P09972 | Energy/metabolism | 39325 |
| Galectin-3 binding protein precursor§ | Q08380 | Cell Adhesion/Communication | 65331 |
| Galectin-7§ | P47929 | Cell Adhesion/Communication | 14944 |
| Gelsolin precursor§ | P06396 | Structural/Cytoskeletal | 85698 |
| Genome polyprotein# | P17593 | Micro organism | 255497 |
| Glucose-6-phosphate isomerase§ | P06744 | Energy/metabolism | 63016 |
| Glutaminyl-tRNA synthetase# | Q8EG26 | Micro organism | 64103 |
| Glutathione S-transferase P | P09211 | Signalling | 23225 |
| Glyceraldehyde-3-phosphate dehydrogenase 1 | P04406 | Energy/metabolism | 35922 |
| Haptoglobin precursor | P00738 | Transport | 45205 |
| Heat shock 70 kDa protein 1§ | P08107 | Protein Folding/Repair | 70052 |
| Heat shock cognate 71 kDa protein§ | P11142 | Protein Folding/Repair | 70898 |
| Hemoglobin alpha chain | P69905 | Transport | 15126 |
| Hemoglobin beta chain | Q9UK54 | Transport | 13964 |
| Hemopexin precursor§ | P02790 | Transport | 51676 |
| Hurpin | Q9UIV8 | Protein Degradation/Inhibitor | 44276 |
| Hypothetical 84.6 kDa protein# | Q04263 | Micro organism | 84602 |
| Ig alpha-1 chain C region | P01876 | Defense/Immunoresponse | 37655 |
| Ig alpha-2 chain C region§ | P01877 | Defense/Immunoresponse | 36508 |
| Ig gamma-1 chain C region§ | P01857 | Defense/Immunoresponse | 36106 |
| Ig gamma-2 chain C region§ | P01859 | Defense/Immunoresponse | 35885 |
| Ig heavy chain V region MOPC 47A# | P01786 | Defense/Immunoresponse | 12975 |
| Ig heavy chain V-II region NEWM# | P01825 | Defense/Immunoresponse | 12790 |
| Ig heavy chain V-III region GAL§,# | P01781 | Defense/Immunoresponse | 12731 |
| Ig heavy chain V-III region HIL# | P01771 | Defense/Immunoresponse | 13566 |
| Ig heavy chain V-III region TUR§,# | P01779 | Defense/Immunoresponse | 12431 |
| Ig heavy chain V-III region VH26 precursor# | P01764 | Defense/Immunoresponse | 12582 |
| Ig kappa chain C region# | P01834 | Defense/Immunoresponse | 11609 |
| Ig kappa chain V-I region CAR§ | P01596 | Defense/Immunoresponse | 11608 |
| Ig kappa chain V-I region WEA§,# | P01610 | Defense/Immunoresponse | 11704 |
| Ig kappa chain V-I region | P01611 | Defense/Immunoresponse | 11840 |
| Ig kappa chain V-III region B6§,# | P01619 | Defense/Immunoresponse | 11636 |
| Ig kappa chain V-III region GOL§ | P04206 | Defense/Immunoresponse | 11830 |
| Ig kappa chain V-IV region Len§ | P01625 | Defense/Immunoresponse | 12640 |
| Ig lambda chain C regions# | P01842 | Defense/Immunoresponse | 11237 |
| Ig lambda chain V-I region NEW# | P01701 | Defense/Immunoresponse | 11453 |
| Ig lambda chain V-I region WAH§,# | P04208 | Defense/Immunoresponse | 11725 |
| Ig lambda chain V-III region LOI§ | P80748 | Defense/Immunoresponse | 11935 |
| Ig lambda chain V-III region SH§ | P01714 | Defense/Immunoresponse | 11393 |
| Ig lambda chain V-IV region Hil | P01717 | Defense/Immunoresponse | 11517 |
| Ig mu chain C region | P01871 | Defense/Immunoresponse | 49557 |
| Immunoglobulin J chain§ | P01591 | Defense/Immunoresponse | 15594 |
| Interleukin-1 receptor antagonist prec. | P18510 | Defense/Immunoresponse | 20055 |
| Kallikrein 1 precursor | P06870 | Protein Degradation/Inhibitor | 28890 |
| Keratin, type I cuticular HA3-II§,# | Q14525 | Structural/Cytoskeletal | 46214 |
| Keratin, type I cytoskeletal 10 | P13645 | Structural/Cytoskeletal | 59519 |
| Keratin, type I cytoskeletal 14§,# | P02533 | Structural/Cytoskeletal | 51490 |
| Keratin, type I cytoskeletal 16§ | P08779 | Structural/Cytoskeletal | 51137 |
| Keratin, type I cytoskeletal 9§ | P35527 | Structural/Cytoskeletal | 62129 |
| Keratin, type I microfibrillar 48 kDa# | P02534 | Structural/Cytoskeletal | 46674 |
| Keratin, type II cuticular HB4# | Q9NSB2 | Structural/Cytoskeletal | 64895 |
| Keratin, type II cytoskeletal 1# | P04104 | Structural/Cytoskeletal | 65092 |
| Keratin, type II cytoskeletal 1§ | P04264 | Structural/Cytoskeletal | 65886 |
| Keratin, type II cytoskeletal 2 epidermal§ | P35908 | Structural/Cytoskeletal | 65865 |
| Keratin, type II cytoskeletal 4§ | P19013 | Structural/Cytoskeletal | 57285 |
| Keratin, type II cytoskeletal 5§ | P13647 | Structural/Cytoskeletal | 62447 |
| Keratin, type II cytoskeletal 6A | P02538 | Structural/Cytoskeletal | 59914 |
| Keratin, type II cytoskeletal 6D# | P48667 | Structural/Cytoskeletal | 42468 |
| Keratin, type II cytoskeletal 6E | P48668 | Structural/Cytoskeletal | 59894 |
| Keratin, type II microfibrillar, component 7C# | P15241 | Structural/Cytoskeletal | 53682 |
| Lactoperoxidase precursor | P22079 | Redox | 80288 |
| Lactotransferrin precursor§ | P02788 | Transport | 78182 |
| Leukotriene A-4 hydrolase | P09960 | Energy/metabolism | 69154 |
| L-lactate dehydrogenase A chain§ | P00338 | Energy/metabolism | 36558 |
| L-lactate dehydrogenase B chain§ | P07195 | Energy/metabolism | 36507 |
| Long palate, lung and nasal epith. carc.ass. prot.1prec. | Q8TDL5 | Defense/Immunoresponse | 52442 |
| L-plastin§ | P13796 | Structural/Cytoskeletal | 70158 |
| Lysozyme C precursor | P61626 | Protein Degradation/Inhibitor | 16537 |
| Macrophage capping protein | P40121 | Structural/Cytoskeletal | 38518 |
| Malate dehydrogenase, cytoplasmic | P40925 | Energy/metabolism | 36295 |
| Maspin precursor | P36952 | Protein Degradation/Inhibitor | 42138 |
| Matrix metalloproteinase-9 precursor§ | P14780 | Protein Degradation/Inhibitor | 78427 |
| Maturase K# | Q9GI85 | Micro organism | 61017 |
| Metalloproteinase inhibitor 1 prec.§ | P01033 | Protein Degradation/Inhibitor | 23171 |
| Moesin | P26038 | Structural/Cytoskeletal | 67689 |
| Monocyte differentiation antigen CD14 precursor§,# | P08571 | Defense/Immunoresponse | 40076 |
| Mucin 5B precursor | Q9HC84 | Cell Adhesion/Communication | 590499 |
| Myeloperoxidase precursor | P05164 | Defense/Immunoresponse | 83869 |
| Myoglobin# | P02144 | Transport | 17053 |
| Myosin heavy chain, non-muscle type A§ | P35579 | Structural/Cytoskeletal | 226401 |
| N-acetylglucosamine kinase# | Q9UJ70 | Energy/metabolism | 37244 |
| Neutrophil gelatinase-associated lipocalin prec.§ | P80188 | Transport | 22588 |
| Outer membrane usher protein pefC precursor# | P37868 | Micro organism | 86370 |
| Peptidyl-prolyl cis-trans isomerase A | P62937 | Protein Folding/Repair | 17881 |
| Peroxiredoxin 5, mitochondrial precursor | P30044 | Redox | 22026 |
| Peroxiredoxin 6 | P30041 | Redox | 24904 |
| Phosphatidylethanolamine-binding protein | P30086 | Protein Degradation/Inhibitor | 20926 |
| Phosphoglucomutase§,# | P36871 | Energy/metabolism | 61318 |
| Phosphoglycerate kinase 1 | P00558 | Energy/metabolism | 44483 |
| Phosphoglycerate mutase 1 | P18669 | Energy/metabolism | 28673 |
| Phospholipid transfer protein prec.§,# | P55058 | Energy/metabolism | 54739 |
| Plasminogen activator inhibitor-2 prec.# | P05120 | Signalling | 46596 |
| Polymeric-immunoglobulin receptor precursor | P01833 | Defense/Immunoresponse | 83314 |
| Proactivator polypeptide precursor | P07602 | Protein Degradation/Inhibitor | 58113 |
| Profilin-1§ | P07737 | Structural/Cytoskeletal | 14923 |
| Prolactin-inducible protein precursor§ | P12273 | Defense/Immunoresponse | 16572 |
| Proline-rich protein 3 precursor peptide P-B) | P02814 | Unknown | 8188 |
| Prominin 1 precursor# | O43490 | Signalling | 97202 |
| Protein-glutamine glutamyltransferase E prec.§ | Q08188 | Energy/metabolism | 76632 |
| Purine nucleoside phosphorylase | P00491 | Energy/metabolism | 32118 |
| Pyruvate kinase, isozymes M1/M2§ | P14618 | Energy/metabolism | 57806 |
| Rab GDP dissociation inhibitor beta | P50395 | Signalling | 50663 |
| Ras-related C3 botulinum toxin substrate 2# | P15153 | Transport | 21429 |
| Rho GDP-dissociation inhibitor 2 | P52566 | Signalling | 22857 |
| S100 calcium-binding protein A7§ | P31151 | Cell Growth/Differentiation | 11326 |
| Salivary alpha-amylase precursor | P04745 | Energy/metabolism | 57768 |
| Serine/threonine-protein kinase BRI1- like 2 precursor# | Q9ZPS9 | Energy/metabolism | 39280 |
| Serine/threonine-protein kinase RIPK4# | P57078 | Energy/metabolism | 91611 |
| Serotransferrin precursor§ | P02787 | Transport | 77050 |
| Short palate, lung and nasal epith.carc.ass.prot.2prec. | Q96DR5 | Transport | 27011 |
| Small proline-rich protein 3 | Q9UBC9 | Structural/Cytoskeletal | 18154 |
| SPARC-like protein 1 precursor | Q14515 | Protein Degradation/Inhibitor | 75216 |
| Squamous cell carcinoma antigen 1§ | P29508 | Protein Degradation/Inhibitor | 44565 |
| Sugar fermentation stimulation protein homolog# | Q97VP5 | Micro organism | 27830 |
| Thioredoxin§ | P10599 | Redox | 11606 |
| Transaldolase | P37837 | Energy/metabolism | 37540 |
| Transcobalamin I precursor | P20061 | Transport | 48195 |
| Transgelin-2 | P37802 | Structural/Cytoskeletal | 22260 |
| Transketolase§ | P29401 | Energy/metabolism | 67878 |
| Triosephosphate isomerase isomerise§ | P60174 | Protein Folding/Repair | 26538 |
| Tyrosine recombinase xerC | Q8UC70 | Micro organism | 34532 |
| Ubiquitin# | O46543 | Protein Degradation/Inhibitor | 8583 |
| Von Ebner’s gland protein precursor | P31025 | Transport | 19250 |
| Zinc-alpha-2-glycoprotein precursor§ | P25311 | Energy/metabolism | 33872 |
| 95% confidence proteins | |||
| 14-3-3 protein sigma§ | P31947 | Signalling | 27774 |
| 30S ribosomal protein S20# | Q7VQL2 | Micro organism | 10264 |
| 50S ribosomal protein L5# | Q8CRH2 | Micro organism | 20236 |
| Acetyl-CoA acetyltransferase# | P45359 | Energy/metabolism | 41241 |
| Alanyl-tRNA synthetase# | Q971J4 | Micro organism | 103675 |
| Alpha-2-macroglobulin precursor§ | P01023 | Protein Degradation/Inhibitor | 163278 |
| Bact.l/permeability-increasing protein- like 1 prec. | Q8N4F0 | Transport | 49172 |
| Beta crystallin B1 (Beta-35)# | P53674 | Cell Growth/Differentiation | 27892 |
| Carbonyl reductase [NADPH] 1# | P16152 | Energy/metabolism | 30244 |
| Carcinoembryonic antigen-related cell adh. mol.5prec.§,# | P06731 | Defense/Immunoresponse | 76796 |
| Catalase§ | P04040 | Redox | 59625 |
| CD9 antigen (p24)# | P21926 | Cell Adhesion/Communication | 25285 |
| Chaperone protein htpG | P61185 | Micro organism | 73731 |
| Cystatin B# | Q862Z5 | Protein Degradation/Inhibitor | 11103 |
| Dihydrolipoyllysine-residue succinyltransferase# | P36957 | Energy/metabolism | 48640 |
| Ethanolamine utilization protein# | P41793 | Micro organism | 49174 |
| F-actin capping protein alpha-2 subunit# | P47755 | Structural/Cytoskeletal | 32818 |
| Ferredoxin II# | P00237 | Micro organism | 9962 |
| Genome polyprotein# | P17594 | Micro organism | 255428 |
| Glucose-6-phosphate 1-dehydrogenase# | P11413 | Energy/metabolism | 59135 |
| Heat shock protein HSP 90-beta# | P08238 | Protein Folding/Repair | 83133 |
| Hut operon positive regulatory protein# | P10943 | Micro organism | 16064 |
| Hypothetical protein ynaA# | P77658 | Micro organism | 37060 |
| Hypothetical UPF0135 protein CPn0137# | Q9Z946 | Micro organism | 27236 |
| Ig heavy chain V region UPC10§,# | P01811 | Defense/Immunoresponse | 13001 |
| Ig kappa chain V-II region TEW§ | P01617 | Defense/Immunoresponse | 12316 |
| Ig kappa chain V-III region NG9 precursor§,# | P01621 | Defense/Immunoresponse | 10729 |
| Myeloblastin precursor | P24158 | Protein Degradation/Inhibitor | 27807 |
| Potential phospholipid-transporting ATPase VA# | O60312 | Energy/metabolism | 167688 |
| Probable Na(+)/H(+) antiporter nhx-9 | P35449 | Micro organism | 75281 |
| Probable serine/threonine-protein kinase# | P28966 | Micro organism | 65248 |
| Pyruvate kinase, isozymes R/L# | P30613 | Energy/metabolism | 61830 |
| Rho GDP-dissociation inhibitor 1 | P52565 | Signalling | 23076 |
| Serum albumin precursor§ | P02768 | Transport | 69367 |
| Vinculin# | P18206 | Cell adhesion/Communication | 123668 |
| Zinc finger protein 446# | Q9NWS9 | Signalling | 48957 |
§
Proteins that are also found in plasma according to the HUPO Plasma Proteome Initiative list of plasma proteins (www.bioinformatics.med.umich.edu/app/hupo/ppp/).
#
Novel saliva proteins identified in this study compared to seven previous studies (see Fig. 7).