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. 2008 Nov 5;28(45):11477–11487. doi: 10.1523/JNEUROSCI.2816-08.2008

Figure 5.

Figure 5.

Effects of dietary folate deficiency on plasma and regional brain metabolites in wild-type mice. A, B, Groups of 1-month-old C57BL/6J wild-type male mice were fed for 8 weeks on amino acid-defined diets that contain either normal folate levels (NF; 6.7 mg/kg folic acid; white bars) or low folate levels (LF; 0.2 mg/kg folic acid; gray bars) or were folate deficient (FD; 0 mg/kg folic acid; black bars). Data are mean ± SD, n = 6 mice per group; #p < 0.001; *p < 0.05. A, Total plasma Hcy and plasma folate. B, Regional brain tissue SAM and SAH levels and SAM/SAH ratio. “Cortex” is defined as the cortical region minus the frontal cortex.