A, B, Development of seizures after injection into CA3 of kainic acid (A) and bicuculline (B). To adjust similar time for behavioral seizure occurrence, a 30 s break was used in the tracings with kainic acid injection. In the case of kainic acid injection, the most significant changes occurred outside the area of injection, whereas after bicuculline injection, the most dramatic changes occurred within the area of injection and immediate surrounding areas: RpDG and REC. LaDG and RaDG, Left and right anterior dentate gyrus, respectively; LEC, left entorhinal cortex.