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. Author manuscript; available in PMC: 2009 May 29.
Published in final edited form as: Mech Ageing Dev. 2008 Jun 27;129(10):580–592. doi: 10.1016/j.mad.2008.06.001

Figure 5.

Figure 5

Clustering coefficient. Green bars represent average clustering coefficients for CR-downregulated genes, while red bars represent average clustering coefficients for CR-upregulated genes. For each CR-regulated gene, the 20 genome-wide nearest neighbor transcripts were identified, and the clustering coefficient associated with each CR-regulated gene was calculated. The cluster coefficient ranges from 0 to 1 and measures the local density of expression networks surrounding a given node (transcript) (see Equation 5 from Dong and Horvath (2007)). Values near 0 indicate weak connectivity among neighbors at an individual node, while values near 1 indicate strong connectivity among neighbors at an individual node. Nearly identical results were obtained using the “line density” measure of local connectivity (see Equation 2 from Dong and Horvath (2007)).