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Twist-1 is induced upon PPARδ activation in the brown fat. (A) Twist-1 expression in differentiated brown fat adipocytes treated with vehicle or PPAR agonists for 24 h. (B) PPARδ associates with the twist-1 promoter. (C) Twist-1 expression in the brown fat of C57BL6 mice treated with the PPAR agonists (n=5 mice per group). (D) Twist-1 expression in the brown fat of lean and obese mice (n=3 mice per group). (E) A coordinated transcriptional regulatory network in brown fat metabolism.
