Figure 4.

Expression of β2 integrin Mac-1 on the surface of isolated neutrophils before and 120 min after an oral 75 g glucose load in 11 patients with postprandial hyperglycemia (fasting plasma glucose level <126 mg/dl and glucose level at 120 min ≥ 200 mg/dl), 9 patients with impaired glucose tolerance (IGT) (fasting plasma glucose level <126 mg/dl and glucose level at 120 min ≥ 140 mg/dl) and 12 patients with normal glucose tolerance (fasting plasma glucose level <126 mg/dl and glucose level at 120 min <140 mg/dl). In patients with postprandial hyperglycemia, Mac-1 expression on unstimulated neutrophils was upregulated at 120 min after glucose loading compared to baseline. In addition, fMLP-induced upregulation of Mac-1 was enhanced significantly at 120 min in both patients with postprandial hyperglycemia and patients with IGT. In contrast, these changes were not evident in patients with normal glucose tolerance.