Table 6.
Difference in mean Weschler intelligence scale for children (WISC-III) scores for resuscitated infants, with or without symptoms of encephalopathy, compared with the reference group
| Unadjusted mean difference | p value | Adjusted mean difference* | p value | ||
|---|---|---|---|---|---|
| Verbal subtests | |||||
| Information (n=5937) | |||||
| Asymptomatic resuscitated infants | −0·02 (−0·34 to 0·30) | 0·891 | −0·11 (−0·42 to 0·20) | 0·480 | |
| Resuscitated infants with encephalopathy | −0·65 (−1·86 to 0·56) | 0·295 | −1·43 (−2·93 to 0·06) | 0·061 | |
| Arithmetic (n=5927) | |||||
| Asymptomatic resuscitated infants | −0·15 (−0·57 to 0·26) | 0·470 | −0·09 (−0·51 to 0·34) | 0·689 | |
| Resuscitated infants with encephalopathy | −0·68 (−2·27 to 0·91) | 0·402 | −0·61 (−2·65 to 1·44) | 0·562 | |
| Vocabulary (n=5910) | |||||
| Asymptomatic resuscitated infants | 0·05 (−0·40 to 0·49) | 0·843 | −0·01 (−0·44 to 0·42) | 0·962 | |
| Resuscitated infants with encephalopathy | −1·58 (−3·27 to 0·12) | 0·068 | −2·53 (−4·61 to −0·44) | 0·018 | |
| Comprehension (n=5879) | |||||
| Asymptomatic resuscitated infants | −0·36 (−0·73 to 0·02) | 0·065 | −0·24 (−0·63 to 0·15) | 0·235 | |
| Resuscitated infants with encephalopathy | −2·62 (−4·05 to −1·19) | 0·0003 | −2·28 (−4·16 to −0·39) | 0·018 | |
| Similarities (n=5939) | |||||
| Asymptomatic resuscitated infants | −0·49 (−0·89 to −0·08) | 0·018 | −0·52 (−0·92 to −0·12) | 0·010 | |
| Resuscitated infants with encephalopathy | 0·00 (−1·53 to 1·53) | 0·997 | −0·82 (−2·75 to 1·11) | 0·406 | |
| Performance subtests | |||||
| Picture completion (n=5919) | |||||
| Asymptomatic resuscitated infants | −0·04 (−0·42 to 0·33) | 0·829 | −0·06 (−0·44 to 0·33) | 0·769 | |
| Resuscitated infants with encephalopathy | −1·83 (−3·25 to −0·41) | 0·011 | −1·25 (−3·10 to 0·61) | 0·189 | |
| Coding (n=5934) | |||||
| Asymptomatic resuscitated infants | −0·05 (−0·35 to 0·26) | 0·769 | 0·01 (−0·32 to 0·30) | 0·959 | |
| Resuscitated infants with encephalopathy | −1·13 (−2·29 to 0·03) | 0·057 | −1·46 (−2·95 to 0·03) | 0·054 | |
| Picture arrangement (n=5858) | |||||
| Asymptomatic resuscitated infants | −0·11 (−0·60 to 0·37) | 0·644 | −0·28 (−0·79 to 0·22) | 0·274 | |
| Resuscitated infants with encephalopathy | −1·11 (−2·95 to 0·72) | 0·234 | −1·70 (−4·13 to 0·73) | 0·169 | |
| Block design (n=5900) | |||||
| Asymptomatic resuscitated infants | −0·04 (−0·42 to 0·35) | 0·853 | −0·07 (−0·46 to 0·32) | 0·710 | |
| Resuscitated infants with encephalopathy | −1·67 (−3·16 to −0·18) | 0·028 | −0·54 (−2·42 to 1·34) | 0·576 | |
| Object assembly (n=5582) | |||||
| Asymptomatic resuscitated infants | 0·00 (−0·39 to 0·39) | 0·995 | 0·04 (−0·37 to 0·44) | 0·847 | |
| Resuscitated infants with encephalopathy | −3·33 (−4·85 to −1·81) | <0·0001 | −3·13 (−5·19 to −1·07) | 0·003 | |
| Summary scores | |||||
| Verbal IQ (n=5913) | |||||
| Asymptomatic resuscitated infants | −1·17 (−2·86 to 0·53) | 0·178 | −1·18 (−2·79 to 0·43) | 0·152 | |
| Resuscitated infants with encephalopathy | −6·56 (−13·00 to −0·12) | 0·046 | −9·15 (−16·95 to −1·35) | 0·022 | |
| Performance IQ (n=5907) | |||||
| Asymptomatic resuscitated infants | −0·33 (−2·05 to 1·40) | 0·710 | −0·52 (−2·25 to 1·20) | 0·553 | |
| Resuscitated infants with encephalopathy | −11·87 (−18·42 to −5·33) | 0·0004 | −9·99 (−18·35 to −1·64) | 0·019 | |
| Full-scale IQ (n=5887) | |||||
| Asymptomatic resuscitated infants | −0·88 (−2·55 to 0·79) | 0·301 | −0·99 (−2·58 to 0·60) | 0·220 | |
| Resuscitated infants with encephalopathy | −10·09 (−16·42 to −3·77) | 0·002 | −10·64 (−18·32 to −2·97) | 0·007 | |
Data are mean difference in IQ scores (95% CI).
*
Adjusted for sex, neonatal sepsis, parity, gestational age, birthweight, length and head circumference, method of birth, ethnicity, housing tenure, crowding index, and maternal hypertension, education, socioeconomic group, car ownership, and age.