Table 1.
Summary of recent studies assessing final height in pediatric renal transplant recipients
| Study | Tx period | Population (n) | rhGH post-Tx (n) | Age at Tx (years) | Follow-up (years) | Height SDSa | Growth determinants | ||
|---|---|---|---|---|---|---|---|---|---|
| At Tx | Final Height | Normal heightb | |||||||
| Andre et al. 2003 [5] | 1975 | 19 (11 boys) | 0 | 13.2 | 10.9 | −3.1 | −2.6 | 42% | Height at ESRD; duration and cause of ESRD |
| Englund et al. 2003 [6] | 1981–1994 | 24 (8 boys) | 6 | 9.5 | 7.6 | −1.7 | −1.1 | 75% | Height at Tx; bone age; graft function |
| Ninik et al. 2002 [7] | 1985–1998 | 82 (53 boys) | 0 | 10.3 | > 5 | −2.1 (n = 82) | −1.3 (n = 47) | - | Height at Tx; age at Tx; final GFR; steroid dose |
| Nissel et al. 2004 [8] | 1983–2002 | 37 (18 boys) | 0 | 10.2 (girls) | 8.5 | −2.9 (girls) | −1.9 (girls) | 68% | Height at Tx; graft function |
| 12.5 (boys) | −1.7 (boys) | −1.0 (boys) | |||||||
| Offner et al. 1999 [9] | 1970–1993 | 100 (47 boys) | 7 | 13.6 | 13.1 | −2.2 | −2.4c | 47%c | - |
| Rodriguez-Soriano et al. 2000 [10] | 1986–1999 | 32 (17 boys) | 3 | 12.1 | 7.2 (median) | −1.6 (girls) | −1.2 (girls) | 69% | Height at Tx and at start of dialysis; duration of dialysis |
| −1.4 (boys) | −1.6 (boys) | ||||||||
Tx Transplantation, ESRD end stage renal disease, GFR glomerular filtration rate, SDS standard deviation score, rhGH recombinant human growth hormone
aHeight values are expressed in SDS compared with local measurements
bNormal height is defined as a final height > − 2 SDS
cFinal height in 84 non-cystinotic patients: −1.8 SDS (56% achieved normal height)