Table 4.
Toxicity results
| Toxicity gradea | Grade 1 | Grade 2 | Grade 3 | Grade 4 |
|---|---|---|---|---|
| No. of patients (%) | No. of patients (%) | No. of patients (%) | No. of patients (%) | |
| Hematological toxicity | ||||
| Anemia | 1 (2.6) | 7 (18.4) | 0 | 0 |
| Leucocytopenia | 1 (2.6) | 6 (15.8) | 0 | 0 |
| Neutropenia | 11 (28.9) | 6 (15.8) | 2 (5.3) | 0 |
| Thrombocytopenia | 2 (5.3) | 0 | 0 | 0 |
| Elevated ALP | 17 (44.7) | 2 (5.3) | 0 | 0 |
| Elevated AST | 14 (36.8) | 3 (7.9) | 0 | 0 |
| Elevated ALT | 12 (31.6) | 1 (2.6) | 0 | 0 |
| Elevated γ-GTP | 8 (21.1) | 3 (7.9) | 2 (5.3) | 0 |
| Elevated T-Bil | 11 (28.9) | 5 (13.2) | 0 | 0 |
| Elevated creatinine | 1 (2.6) | 0 | 0 | 0 |
| Hypercalcemia | 16 (42.1) | 1 (2.6) | 0 | 0 |
| Hypoalbuminemia | 12 (31.6) | 0 | 0 | 0 |
| Nonhematological toxicity | ||||
| Hand–foot syndrome | 16 (42.1) | 5 (13.2) | 3 (7.9) | 0 |
| Mucositis | 11 (28.9) | 0 | 0 | 0 |
| Nausea | 8 (21.1) | 0 | 0 | 0 |
| Vomiting | 4 (10.5) | 0 | 0 | 0 |
| Diarrhea | 7 (18.4) | 1 (2.6) | 1 (2.6) | 0 |
| Constipation | 0 | 0 | 1 (2.6) | 0 |
| Abdominal pain | 1 (2.6) | 0 | 0 | 0 |
| Edema | 3 (7.9) | 0 | 0 | 0 |
| Rash | 1 (2.6) | 0 | 0 | 0 |
| Hyperpigmentation | 5 (13.2) | 0 | 0 | 0 |
| Pruritus | 1 (2.6) | 0 | 0 | 0 |
| Injection site reaction | 1 (2.6) | 0 | 0 | 0 |
| Nail changes | 1 (2.6) | 1 (2.6) | 0 | 0 |
| Ulceration | 1 (2.6) | 0 | 0 | 0 |
| Cervical pain | 1 (2.6) | 0 | 0 | 0 |
| Chest pain | 2 (5.3) | 0 | 0 | 0 |
| Cough | 2 (5.3) | 1 (2.6) | 0 | 0 |
| Sputum | 0 | 1 (2.6) | 0 | 0 |
| Dyspnea | 0 | 1 (2.6) | 0 | 0 |
| Fever | 3 (7.9) | 1 (2.6) | 0 | 0 |
| Fatigue | 10 (26.3) | 2 (5.3) | 0 | 0 |
| Appetite loss | 2 (5.3) | 1 (2.6) | 0 | 0 |
| Weight loss | 0 | 1 (2.6) | 0 | 0 |
| Headache | 5 (13.2) | 0 | 0 | 0 |
| Dizziness | 1 (2.6) | 0 | 0 | 0 |
| Voice changes | 1 (2.6) | 0 | 0 | 0 |
| Impaired motor function | 4 (10.5) | 0 | 0 | 0 |
| Photophobia | 0 | 1 (2.6) | 0 | 0 |
| Cataract | 0 | 1 (2.6) | 0 | 0 |
| Back pain | 1 (2.6) | 0 | 0 | 0 |
| Urinary retention | 1 (2.6) | 0 | 0 | 0 |
| Pain on urination | 1 (2.6) | 0 | 0 | 0 |
aAccording to National Cancer institute common Toxicity Criteria