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. 2008 Oct 31;11(2):217–229. doi: 10.1111/j.1462-5822.2008.01248.x

Fig. 6.

Fig. 6

Expression of ELMO1 causes a shift from lamellipodia to membrane ruffles. A. Swiss 3T3 cells were mock transfected or transfected with GFP tagged ELMO1 18 h prior to infection with wild-type E2348/69 or E2348/69 expressing EspT. While wild-type E2348/69 displayed only pedestal formation in mock transfected or cells transfected with ELMO1, E2348/69 expressing EspT induced formation of lamellipodia on mock transfected cells but in cells transfected with ELMO there was a shift from lamellipodia to membrane ruffles. B. Quantification of Lamellipodia and membrane ruffles on mock transfected Swiss 3T3 or Swiss 3T3 cells transfected with ELMO1 after 90 min infection with wild-type E2348/69 or E2348/69 expressing EspT. One hundred cells were counted in triplicate in three independent experiments. Results are displayed as mean ± SEM.