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. 2009 Apr 15;29(15):4846–4857. doi: 10.1523/JNEUROSCI.0563-09.2009

Figure 8.

Figure 8.

Intra-NAc infusions of SR141716A reduce cocaine breakpoints in LgA but not ShA rats. SR141716A (SR, Rimonabant) was infused locally into the NAc shell immediately before the test session (a). Sessions under a PR schedule ended when rats did not achieve cocaine (0.5 mg/kg/infusion) reinforcement within 1 h. Data in a are expressed as the mean ± SEM of the number of cocaine infusions per session on the left axis and the breakpoint (maximal ratio per infusion) on the right axis. Bars on the left side (a) are data from cocaine extended-access (LgA) rats, and bars on the right side are data from limited-access (ShA) rats. Bilateral infusions of SR141716A (3.0 μg/side) decreased the breakpoint for cocaine selectively in LgA rats compared with vehicle-injected animals. Different from vehicle-injected rats in the same access condition, **p < 0.01. Different from ShA vehicle-injected rats, #p < 0.05. Cocaine self-administration data (FR1) during the entire session (b) and the first hour of the session during the escalation period (c) are represented in the bottom graphs. Filled circles represent cocaine (0.5 mg/kg/infusion) extended-access rats (6 h session, LgA), and open circles correspond to cocaine-limited-access rats (1 h session; ShA). Data are expressed as the mean ± SEM of the number of cocaine infusions on the left axis and milligrams per kilograms on the right axis. *p < 0.05, **p < 0.01, ***p < 0.001 compared with session one.