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. Author manuscript; available in PMC: 2010 May 15.
Published in final edited form as: Cancer Res. 2009 Apr 28;69(10):4209–4216. doi: 10.1158/0008-5472.CAN-08-4934

Fig. 3. Gefitinib suppresses heregulin-induced signaling.

Fig. 3

GH4C1 cells were serum-starved overnight, pre-treated with gefitinib (Gf) (indicated concentrations) for 45 min prior to induction with HRG (6 nM; 10 min). Immunoprecipitations and immunoblotting were performed as for Fig. 2. GH and PRL secretion in the culture medium were determined as for Fig. 1. ***, p<0.001 vs. control group; #, p<0.001 vs. HRG only group. A representative of 3 independently performed experiments is shown.