Table 1.

Sequence features of wild type and redesigned tenascin.

Protein	TEN-WT	TEN-D1	TEN-D2	TEN-D3
MW ( Da )	9895.9	9729.7	9800.0	9790.1
Theoretical PI	4.15	4.99	5.10	4.72
Fraction of positively charged residues	0.09	0.07	0.07	0.06
Fraction of negatively charged residues	0.20	0.08	0.08	0.08
Fraction of hydrophobic residues	0.38	0.37	0.42	0.42
Sequence identity to WT ( overall )	/	31/89	36/89	38/89
Sequence identity to WT ( buried* )	/	9/20	11/20	12/20
Sequence identity to TEN-D1 ( overall )	31/89	/	45/89	48/89

^*buried – Buried residues have more than 19 neighbors within 10Å.