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. Author manuscript; available in PMC: 2010 May 1.
Published in final edited form as: J Autoimmun. 2009 Mar 26;32(3-4):149–157. doi: 10.1016/j.jaut.2009.02.009

Figure 5. Induction of BAFF.

Figure 5

A) Splenocytes were isolated from 5 to 10 month-old R4A mice or R4A × FcγRIIB-/- mice (n = 6 for each) and analyzed for baff mRNA by qPCR. The data were normalized to polr2a which revealed an increase in baff mRNA in R4A × FcγRIIB-/- mice. B) Serum BAFF levels were measured by ELISA for aged-matched WT BALB/c (n = 12), FcγRIIB-/- (n = 13), R4A (n = 16) and R4A × FcγRIIB-/- (n = 15) mice. **BAFF serum levels were significantly increased in R4A × FcγRIIB-/- mice compared to R4A (p < 0.0001), FcγRIIB-/- (p < 0.0008) or WT (p < 0.0001) BALB/c mice. Statistical significance was determined by Mann-Whitney. Data are shown as the mean ± SD.