Figure 3.

Gαs*^str mice showed an increase in anxiety-related behaviors in the light/dark box and elevated zero maze. A, Relative to control littermates (CT), Gαs*^str transgenic mice exhibited a longer latency to enter the lit chamber of the light/dark box; however, Gαs*^str-dev and Gαs*^str-dox mice showed normal behavior. B, Gαs*^str mice also spent less time in total in the lit portion of the box. Surprisingly, Gαs*^str-dev mice also showed this decrease in time spent in the light. Importantly, however, Gαs*^str-dox mice exhibited normal performance. C, Gαs*^str mice also exhibited significantly longer latencies to enter the open quadrants of an elevated zero maze and D) and spent less time overall in the open quadrants. Gαs*^str-dev mice and Gαs*^str-dox mice were normal on all elevated zero maze measures. The asterisk (*) versus CT, p < 0.05–0.01.