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. 2009 Jun 9;4(6):e5844. doi: 10.1371/journal.pone.0005844

Figure 2. Activation of CB2 receptors by JWH-133 enhances fat inflammation in HFD-fed mice.

Figure 2

WT mice were fed a HFD or a ND for 6 weeks, and treated with JWH-133 (3 mg/kg) or vehicle i.p daily during the last 15 days. A, Body weight progression during JWH-133 treatment. B, JWH-133 increases adipose tissue inflammation. Fold induction of adipose tissue Emr1, Tnf and Ccl2 expression over control conditions (ND-fed mice injected with vehicle). C, Activation of CB2 receptors with 1 µM JWH-133 for 48 hours up-regulates Tnf and Ccl2 expression in explants isolated from ob/ob mice fat pads. D, Impact of JWH-133 on hepatic inflammation. Fold induction of hepatic Emr1, Tnf and Ccl2 expression over control conditions (ND-fed mice injected with vehicle). *p<0.05 for JWH-133 vs vehicle. #p<0.05 for HFD-fed vs ND-fed mice.