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. 2009 Jun 8;4(6):e5834. doi: 10.1371/journal.pone.0005834

Figure 2. Human ataxin-3 and its closest homologues contain conserved nuclear import sequences.

Figure 2

Sequence alignment of human (H. sapiens), wild boar (S. scrofa), mouse (M. musculus), rat (R. norvegicus), and chicken (G. gallus) ataxin-3. Identical residues are shown in white against a red background; conserved residues are shown in red. The conserved NLS sequence is highlighted by blue triangles below the alignment; the tested hydrophobic putative NES sequences are indicated by blue stars. The Josephin domain (JD) corresponds to residues 1 to 182, the UIM1 to residues 225 to 240 and the UIM2 to residues 246 to 259. The figure was prepared with ESPript [68].