Table 2. Microbial genomic mutation rates calculated using the CT method.

Organism	Mutation reportera	μg(I) (−HS)b	μg(B) (CTs)c	μg (−HS)b
Phage M13	lacZα	0.00103	0.0038 (245)	0.0048
Phage λ	cII	0.00041	0.0022 (8)	0.0026
Phage T4	rI	0.00079	0.0030 (6)	0.0038
Herpes simplex virus	tk	0.00083	0.0035 (5)	0.0043
Escherichia coli	lacI	0.00230 (0.00042)	0.0025 (24)	0.0048 (0.0030)
Saccharomyces cerevisiae	URA3 (4)	0.00016	0.0029 (108)	0.0030
	CAN1 (3)	0.00056	0.0058 (76)	0.0063
Schizosaccharomyces pombe	ura4	0.00031	0.0019 (5)	0.0022
	ura5	0.00050	0.0034 (4)	0.0039
Mesophile mean		0.00077 (0.00056)	0.0032	0.0040 (0.0038)
Mesophile range		15-fold (6.7-fold)	3.0-fold	2.9-fold (2.9-fold)
Sulfolobus acidocaldarius	pyrEF	0.00053 (0.00026)	0.00011 (1)	0.00065 (0.00037)
Thermus thermophilus	pyrEF	0.00038 0.00013	0.00054 (2)	0.00093 (0.00067)
Thermophile mean		0.00046 (0.00019)	0.00033	0.00079 (0.00052)
Thermophile range		1.4-fold (2.0-fold)	4.8-fold	1.4-fold (1.8-fold)
Mean (mesophile/thermophile)		1.7 (2.9)	9.8	5.1 (7.2)

μ_g(I) = genomic indel rate. μ_g(B) = genomic base-pair substitution rate. μ_g = μ_g(I)+μ_g(B).

^a(Number of values averaged).

^b(Value excluding a large frameshift hotspot).

^c(Number of chain-terminating mutations or equivalent).