Fig. 1.

Genome browser displays (drawn in Canvas) showing SFP, mSFP and SNP, and probes at the pfmdr-1 locus. (A) A genome browser window (~5 kb) showing chromosomal region covering pfmdr-1 gene (top line) and the predicted pfmdr-1 coding region (black bar); blue circle, known SNPs reported previously [21,56], black stars, SNPs in PlasmoDB; red squares, SFPs detected by individual probe and mSFP by a majority of the probes; green bars, genomic probe covering the pfmdr-1 gene. Names of the SNPs and probes are as labeled. Note the mSFP matched well with those known SNPs. (B and C) An expanded view (500-bp window) showing 2 regions in the pfmdr-1, including 2 known substitutions (PFE1150w-1 and PFE1150w-4) that were not covered by any of the genomic probes. The labels are the same as in (A). For more information on genome-wide SNPs and SFPs, please visit: http://p-falcip.abcc.ncifcrf.gov/cgi-bin/gbrowse/malaria_sanger/.