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CD 45 expression is reduced after 6 months of systemic anti-Aβ antibody administration and these reductions are maintained 3 months after the cessation of treatment. A and B show CD 45 immunoreactivity in the frontal cortex of Tg2576 mice that received control antibody at 14 months of age and at 17 months of age, respectively. C and D show CD 45 immunoreactivity in Tg2576 mice that received anti-Aβ antibody at 14 months of age and at 17 months of age. Scale bar, 120 μm.
