Table 2.
Overview on features of the used R-/G-band-assigned pools
| 12 R (20 BACs) |
12 G (28 BACs) |
18 R (15 BACs) |
18 G (12 BACs) |
19 R (8 BACs) |
19 G (8 BACs) |
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Gene density (2 Mb window) | 16.6 | 8.6 | 7.2 | 4.7 | 32.4 | 30.1 | ||||||
| Gene density (10 Mb window) | 13.4 | 9.4 | 5.7 | 5.0 | 30.9 | 33.5 | ||||||
| Mean replication timing (early-mid-late) | 1.63 (11-7-2) | 1.45 (4-11-13) | 1.55 (2-12-1) | 1.39 (0-5-7) | 1.63 (6-2-0) | 1.56 (4-2-2) | ||||||
| Expression | HLy | HFb | HLy | HFb | HLy | HFb | HLy | HFb | HLy | HFb | HLy | HFb |
| high | 1 | 11 | 1 | 3 | 1 | 1 | 0 | 0 | 0 | 2 | 0 | 3 |
| median | 6 | 7 | 1 | 3 | 1 | 3 | 0 | 2 | 4 | 5 | 2 | 3 |
| low | 13 | 2 | 22 | 18 | 12 | 10 | 8 | 6 | 3 | 0 | 5 | 1 |
| unknown | 0 | 0 | 4 | 4 | 1 | 1 | 4 | 4 | 1 | 1 | 1 | 1 |
Mean gene density, replication timing, and expression levels of R/G band assigned BAC pools of HSA 12, 18, and 19. Numbers in brackets indicate the number of BACs with an early, mid, or late replication timing where each fraction comprises one-third of the entire replication range (theoretically between 1.0 and 2.0) observed for the respective chromosome. Data on “expression” classify BACs according to their genes with only low (<300 transcription units), median (300–1,000 transcription units) and high (>1,000 transcription units) expression levels.