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. Author manuscript; available in PMC: 2009 Jun 1.
Published in final edited form as: Nat Protoc. 2007;2(3):577–587. doi: 10.1038/nprot.2007.53

Figure 1.

Figure 1

Principle of array-CGH. Genomic DNA from two cell populations is differentially labeled and hybridized to a microarray in the presence of Cot1 DNA to suppress repeat sequences. The fluorescent ratios on each array spot are calculated and normalized so that the median log 2 ratio is 0.