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. 1999 May 25;96(11):6377–6381. doi: 10.1073/pnas.96.11.6377

Figure 2.

Figure 2

Aspirin is antiinflammatory in animals rendered deficient in COX-2 activity [COX-2 knockouts (KO)]. Air pouches were formed on female COX-2 knockout mice (C57BL/6; 129–Ptgs2fm1Jed; The Jackson Laboratory) or female wild-type mice (C57BL/6; 129), and the mice were treated with aspirin or saline, as described in Methods. There were significantly fewer leukocytes present in the air pouches of COX-2 knockout mice treated with aspirin (P < 0.01; n = 5) than in those of controls (n = 4). Similarly there were significantly fewer leukocytes present in the air pouches of wild-type mice treated with aspirin (P < 0.05; n = 5) than in those of controls (P < 0.05). The leukocyte counts are shown as means ± SEM.