Table 2.

Genome-wide occurrences of each candidate motif within coding and upstream regions

	Upstream			Coding
Motif	Number of genes	Number of motifs	Number of motifs/10 kb	Number of genes	Number of motifs	Number of motifs/10 kb	p-value
GLYCA	885	2608	2.23	956	3618	2.14	0.0538
GLYCB	418	982	0.84	201	531	0.31	< 0.001
MICA	734	2010	1.72	435	1019	0.6	< 0.001
MICB	223	637	0.54	290	769	0.46	0.0026
NTBA	658	1959	1.67	418	1495	0.89	< 0.001
NTBB	1100	2548	2.18	359	852	0.5	< 0.001
RPA	368	581	0.49	145	262	0.15	< 0.001
RPB	1311	4030	3.45	810	2648	1.57	< 0.001

The number of occurrences of each motif and the genes containing them in the whole genome Motif density (number of motifs per 10 kb) was computed using MAST to search position weight matrix profiles of each motif against custom built databases (upstream regions (11,685,162 bp) and coding regions (16,862,741 bp)).