Table 3.

Number of genes showing changes in early dynamic expression after PMA treatment with promoter regions that are bound by EGR-1

	Number of promoters bound at time points after PMA treatment
	1 hour	2 hours	4 hours	6 hours
Up-regulated	5 (23.8%)	7 (25.0%)	9 (14.3%)	3 (12.5%)
Down-regulated	0 (0%)	0 (0%)	4 (13.8%)	4 (12.9%)

After PMA treatment, 136 genes were up-regulated and 61 down-regulated. Of these, 24 and 8, respectively, were found to be EGR-1 target genes. Percentage values indicate the number of target genes with bound promoters whose expression was up- or down-regulated at the indicated time point out of all EGR-1 target genes up- or down-regulated, respectively, over the entire time course (0-6 hours).