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Dopamine stimulates the release of EGF and EGFR activation from adult SVZ NPCs. (A) EGF release after 24-h treatment with dopamine ± PKC inhibitor, compared with control using an ELISA. ***, P < 0.001; *, P < 0.05. (B) Cell cycle analysis of NPCs using propidium iodide shows that the percentage of cells in S phase treated with dopamine alone is increased and lost when used in combination with an EGFR inhibitor (AG1478). ***, P < 0.001.
