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. 2009 May 7;106(21):8641–8646. doi: 10.1073/pnas.0812255106

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Fig. 1. — Myc deficiency disproportionately impairs iNKT cell development. BALB/c control and CD4Cre Myc^fl/fl mice were analyzed at 4–8 weeks of age. (A) (Upper) Representative FACS plots depicting CD4 and CD8 surface expression on lymphocytes from thymus and spleen. (B) (Upper) Invariant iNKT cell populations in thymus, spleen, and liver. (A and B) (Lower) Absolute cell numbers are given as histograms. N = number of experimental mice per genotype indicated here. B, BALB/c; M, CD4Cre Myc^fl/fl. (C) Quantitative PCR for Myc mRNA expression was performed on cDNA obtained from the indicated cell populations. No Myc expression was detected in CD4 SP or iNKT ST1 cells from CD4Cre Myc^fl/fl mice. (D) iNKT cells from sublethally irradiated bone marrow chimeras were MACS enriched and analyzed by FACS. Host, Thy1.1⁺ BALB/c mice; donor, Thy1.2⁺ CD4Cre Myc^fl/fl mice. Analysis was performed 12 weeks after injection. N = 4.