. 2009 Mar 23;113(22):5536–5548. doi: 10.1182/blood-2008-12-193037

Table 1.

Gene ontology (GO) terms represented among BCL6 target genes

GC-specific genes	Common genes	DLBCL-specific genes	GO term
3 (0)^*	2 (1)^†	1 (1)^†	GO:0043038 amino acid activation
3 (0)^*	2 (1)^†	1 (1)^†	GO:0006418 tRNA aminoacylation for protein translation
3 (0)^*	2 (1)^†	4 (1)^†	GO:0006399 tRNA metabolic process
6 (1)^*	5 (3)^†	9 (4)^†	GO:0034660 ncRNA metabolic process
3 (0)^*	2 (1)^†	1 (1)^†	GO:0043039 tRNA aminoacylation
0 (0)^†	3 (0)^*	0 (0)^†	GO:0045739 positive regulation of DNA repair
0 (0)^†	4 (1)^*	1 (1)^†	GO:0006282 regulation of DNA repair
4 (2)^†	16 (7)^*	12 (8)^†	GO:0006511 ubiquitin-dependent protein catabolic process
4 (2)^†	17 (8)^*	12 (9)^†	GO:0030163 protein catabolic process
4 (2)^†	16 (7)^*	12 (8)^†	GO:0044257 cellular protein catabolic process
8 (4)^†	22 (13)^*	24 (15)^†	GO:0043285 biopolymer catabolic process
4 (2)^†	16 (7)^*	12 (8)^†	GO:0043632 modification-dependent macromolecule catabolic process
4 (2)^†	16 (7)^*	12 (8)^†	GO:0051603 proteolysis involved in cellular protein catabolic process
3 (2)^†	13 (5)^*	8 (6)^†	GO:0051438 regulation of ubiquitin-protein ligase activity
3 (2)^†	13 (5)^*	8 (6)^†	GO:0051340 regulation of ligase activity
3 (1)^†	11 (4)^*	8 (5)^†	GO:0051436 negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle
0 (0)^†	4 (1)^*	3 (1)^†	GO:0009303 rRNA transcription
0 (0)^†	1 (1)^†	7 (2)^*	GO:0000910 cytokinesis
0 (0)^†	1 (1)^†	7 (2)^*	GO:0051301 cell division
6 (3)^†	12 (10)^†	25 (12)^*	GO:0022403 cell cycle phase
3 (1)^†	8 (4)^†	13 (5)^*	GO:0007050 cell cycle arrest
3 (1)^†	7 (3)^†	10 (4)^*	GO:0007067 mitosis
3 (1)^†	8 (4)^†	10 (4)^*	GO:0000087 M phase of mitotic cell cycle
5 (2)^†	10 (7)^†	18 (8)^*	GO:0000279 M phase
6 (4)^†	20 (12)^†	26 (14)^*	GO:0000278 mitotic cell cycle
8 (4)^†	20 (12)^†	30 (14)^*	GO:0034984 cellular response to DNA damage stimulus
9 (5)^†	24 (15)^†	33 (17)^*	GO:0051716 cellular response to stimulus
8 (4)^†	22 (14)^†	32 (16)^*	GO:0033554 cellular response to stress
10 (4)^†	20 (14)^†	28 (16)^*	GO:0006366 transcription from RNA polymerase II promoter
6 (2)^†	10 (7)^†	18 (8)^*	GO:0006414 translational elongation
0 (0)^†	0 (0)^†	3 (0)^*	GO:0018211 peptidyl-tryptophan modification
0 (0)^†	0 (0)^†	3 (0)^*	GO:0018317 protein amino acid C-linked glycosylation via tryptophan
0 (0)^†	0 (0)^†	3 (0)^*	GO:0018406 protein amino acid C-linked glycosylation via 2′-alpha-mannosyl-L-tryptophan
0 (0)^†	0 (0)^†	3 (0)^*	GO:0035269 protein amino acid O-linked mannosylation
0 (0)^†	0 (0)^†	3 (0)^*	GO:0035268 protein amino acid mannosylation
2 (0)^†	1 (1)^†	4 (1)^*	GO:0043631 RNA polyadenylation
5 (3)^†	16 (11)^†	26 (13)^*	GO:0034622 cellular macromolecular complex assembly
9 (4)^†	23 (14)^†	30 (16)^*	GO:0044265 cellular macromolecule catabolic process
5 (4)^†	18 (12)^†	26 (14)^*	GO:0034621 cellular macromolecular complex subunit organization
11 (7)^†	27 (21)^†	39 (24)^*	GO:0022607 cellular component assembly
11 (7)^†	30 (21)^†	39 (25)^*	GO:0043933 macromolecular complex subunit organization
11 (6)^†	27 (20)^†	39 (23)^*	GO:0065003 macromolecular complex assembly
2 (0)^†	0 (2)^†	7 (2)^*	GO:0045333 cellular respiration
0 (1)^†	5 (2)^†	7 (2)^*	GO:0006730 one-carbon compound metabolic process
9 (7)^†	25 (21)^†	45 (24)^*	GO:0006996 organelle organization

The first 3 columns list the number of targets per GO term present among GC-specific, in common between GC and DLBCL and DLBCL-specific genes. The values in parentheses denote the expected number of genes per GO term for each category (ie, GC, common, DLBCL).

The numbers show significant enrichment versus expected (as demonstrated in the heatmap color code in Figure 1A).

^†

The numbers are nonsignificant.