Skip to main content
. Author manuscript; available in PMC: 2009 Oct 1.
Published in final edited form as: Nat Struct Mol Biol. 2009 Mar 15;16(4):397–404. doi: 10.1038/nsmb.1572

Figure 6.

Figure 6

A model for HCV IRES association with the mRNA binding channel of the 40S subunit. Following the association of the HCV IRES with the 40S subunit, domain II is required to promote an open conformation of the mRNA entry channel. The stable association of eIF3 with this complex places eIF3j in the mRNA entry channel, preventing the stable binding of HCV mRNA with the A-site and entry channel. The subsequent recruitment of eIF2-Met-tRNAi is necessary to shift the equilibrium to favor the stability of HCV mRNA in the entry channel over that of eIF3j.

HHS Vulnerability Disclosure