Table 3.
Proposed modified criteria for categorization of Lewy‐related pathology (LRP) in patients with dementia. Results from two autopsy series. Abbreviations: LRP = Lewy‐related pathology; SN = substantia nigra; LADRS = Lewy Body‐Associated Dementia Research Study; ADPR = Alzheimer's Disease Patient Registry; AD = Alzheimer's disease.
| Predominant region | LRP severity scoring with proposed criteria* | Results | ||||
|---|---|---|---|---|---|---|
| SN or medulla† | Amygdala | Cingulate gyrus | Frontal cortex | LADRS n (%) | ADPR n (%) | |
| Brainstem | 1+ in either | 0–2 | 0–1 | 0 | 5 (4%) | 20 (16%) |
| Amygdala | 0–1 in both | 1+ | 0–1 | 0 | 23 (18%) | 24 (19%) |
| Limbic | 1+ in either | 2+ | 1–3 | 0–1 | 26 (21%) | 22 (18%) |
| Neocortical | 1+ in either | 2+ | 2+ | 2+ | 67 (54%) | 55 (44%) |
| Mixed | Cases not classifiable by modified criteria | 4 (3%) | 5 (4%) | |||
*
Severity of LRP was scored according to published consensus criteria as none (0), mild (1), moderate (2), severe (3) or very severe (4) (17).
†
For medulla, the highest score in dorsal motor nucleus of the vagus nerve, raphe nuclei or lateral tegmentum was considered representative and 0 means no LRP in all three subregions of medulla.