Figure 4.

Electron microscopy (low and high magnification) on brain and liver from untreated and NB-DNJ-treated Sandhoff mice (4,800 mg/kg per day for 90 days). Neurons from the polymorph layer of the dentate gyrus: untreated neuron (a and b), NB-DNJ-treated neuron (c and d), untreated hepatocyte (e and f), NB-DNJ-treated hepatocyte (g and h), untreated Kupffer cell (i and j), and NB-DNJ-treated Kupffer cell (k and l). The images are representative of data obtained from at least three mice. The images shown are from female mice, and comparable data were obtained from males (data not shown). (Bar = 0.5 μm.)