Figure 3. Microsatellite marker linkage analysis on chromosome 5 in family 1.

Affected individuals are indicated by black symbols. SLC6A3 gene is located at 5p15.3. Microsatellite markers are positioned according to physical distance (measured in Mb). Haplotypes for these markers are shown, and the disease-associated haplotypes are boxed in blue. Green, pink, and yellow boxes indicate non–disease-associated haplotypes. The 2 affected children shared a common homozygous haplotype in this region. N, novel microsatellite marker.