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. Author manuscript; available in PMC: 2010 May 27.
Published in final edited form as: J Am Chem Soc. 2009 May 27;131(20):7175–7181. doi: 10.1021/ja901307m

Scheme 4.

Scheme 4

Final steps for the synthesis of Py-Im polyamide 1.a

aReagents: (i) NaOH (aq), 1,4-dioxane, 23°C, 11 h, 89%. (ii) DIEA, DMF, PyBOP, 21, 23°C, 12 h, 87%. (iii) DMF, Pd/C, H2 (1 atm), 23°C, 48 h, 81%.