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. 2009 May 15;8:28. doi: 10.1186/1476-4598-8-28

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Copyright © 2009 Kim et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Function and mRNA expression of P-glycoprotein after inhibitor treatment. (A) Doxorubicin efflux was measured after inhibitor treatment. Only C-4 (P-glycoprotein inhibitor) treatment inhibited doxorubicin efflux significantly. (Bcl-2 inh: Bcl-2 inhibitor) (B) mRNA expression of P-glycoprotein was measured by RT-PCR. All inhibitors did not change mRNA expression of P-glycoprotein. mRNA expression of P-glycoprotein of each inhibitor treatment was divided by mRNA expression of DMSO control. (Bcl-2 inh: Bcl-2 inhibitor).