Table 1.
General characteristics of the study population with myocardial infarction (MI) and controls
| Characteristics |
Controlsa (n = 287) |
MIa (n = 394) |
P |
| Age (years) | 58.1 ± 12.6 | 59.9 ± 10.0 | 0.048 * |
| Male sex (%) | 69.0 | 84.0 | <0.001 # |
| BMI (kg/m2) | 25.3 ± 3.4 | 26.6 ± 3.3 | <0.001 * |
| Hypertension (%) | 34.3 | 62.4 | <0.001 # |
| Smoking (%) | 44.9 | 70.8 | <0.001 # |
| Diabetes (%) | 6.2 | 16.2 | <0.001 # |
| Total cholesterol (mmol/L) | 5.54 ± 1.08 | 5.80 ± 1.17 | 0.005 * |
| LDL-cholesterol (mmol/L) | 3.58 ± 0.95 | 3.94 ± 0.99 | <0.001 * |
| HDL-cholesterol (mmol/L) | 1.42 ± 0.40 | 1.19 ± 0.29 | <0.001 * |
| Triglycerides (mmol/L) | 1.51 ± 0.67 | 1.99 ± 1.09 | <0.001 * |
| Apo A-I (g/l) | 1.42 ± 0.27 | 1.28 ± 0.22 | <0.001 * |
| Apo B (g/l) | 1.08 ± 0.26 | 1.23 ± 0.31 | <0.001 * |
| Apo C-III (mg/dl) | 10.8 ± 3.2 | 12.2 ± 4.6 | <0.001 * |
| ApoE (g/l) | 0.043 ± 0.014 | 0.046 ± 0.023 | 0.107 |
| LRP8 R952Q polymorphism (%) | |||
| RR | 43.9 | 38.1 | |
| RQ | 45.3 | 43.9 | 0.027 # |
| 10.8 | 18.0 | ||
| APOE ε2/ε3/ε4 polymorphism (%) | |||
| carrier E2 | 8.7 | 8.6 | |
| E3/E3 | 76.7 | 72.1 | 0.280 # |
| carrier E4 | 14.6 | 19.3 |
a Only 681 subjects with complete analyses of LRP8 R962Q genotypes, APOE genotypes, and the ApoE plasma concentration were included.
*: by t-test
#: by χ2-test