Table 3.

Lipid profile according to APOE ε2/ε3/ε4 polymorphism in non-diabetic subjects without lipid-lowering therapy (n = 449)

APOE ε2/ε3/ε4 variant	Carrier E2 (n = 41)	E3/E3 (n = 333)	Carrier E4 (n = 75)	P *
Total cholesterol (mmol/l)	5.40 ± 1.18	5.73 ± 1.08	6.01 ± 1.10	0.005
LDL-cholesterol (mmol/l)	3.34 ± 0.85	3.85 ± 0.97	4.03 ± 0.96	0.002
HDL-cholesterol (mmol/l)	1.34 ± 0.37	1.31 ± 0.37	1.37 ± 0.45	0.457
Triglyceride (mmol/l)	1.97 ± 1.36	1.65 ± 0.76	1.69 ± 0.91	0.562
Apo A-I (g/l)	1.36 ± 0.25	1.34 ± 0.25	1.36 ± 0.25	0.976
Apo B (g/l)	0.98 ± 0.31	1.16 ± 0.28	1.24 ± 0.28	<0.001
Apo C-III (mg/dl)	12.7 ± 5.7	11.0 ± 3.3	11.1 ± 2.9	0.307
ApoE (g/l)	0.067 ± 0.037	0.042 ± 0.010	0.039 ± 0.011	<0.001

*: by ANOVA with polynomial contrasts for linear trend