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. 2009 May 13;10:43. doi: 10.1186/1471-2199-10-43

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Copyright © 2009 Ng et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Meiotic recombination imprinting at three hotspots within the Kcnq1 domain. Recombination events within the Kcnq1 domain were mapped at hotspot resolution. Hotspot frequencies from reciprocal parental crosses were compared at five novel hotspots. Hotspots Th and Kcnq1 were not affected by parental origin of chromosome. Hotspots Cdkn1c, Slc22a18 and Nap1l4 (boxed) clustered within a 100 kb region and showed meiotic recombination imprinting with higher crossover activity in the CAST♀ × B6♂ direction of the parental cross.