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DB75 subcellular distribution following long-term drug exposure. (A) Trophozoite-infected erythrocytes after exposure to 100 nM DB75 for 24 hours. Note co-localization of DB75 and nuclear DNA stain, Draq5™. (B) Drug was removed by washing at 24 hours and infected erythrocytes incubated for an additional 48 hours in drug-free medium. Note persistent co-localization of DB75 and Draq5™ in nucleus of pycnotic infected erythrocyte.
