Table 2.
Genes specifically affected by organophosphorus pesticide exposure
| Probe Set | WBIDa | Geneb | Description | Biological Role | Dicc | Fend |
| 191443_at | WBGene00013078 | ttr-25 | unknown function – contains transthyretin-like family domain | -5.1 | -5.6 | |
| 192157_at | WBGene00000964 | dhp-2 | dihydropyrimidinase | -2.7 | -2.4 | |
| 187663_at | WBGene00008706 | F11E6.1 | glucocerebrosidase | Lipid metabolism | -2.4 | -2.3 |
| 173412_s_at | WBGene00013077 | ttr-24 | unknown function – contains transthyretin-like family domain | -2.5 | -1.9 | |
| 181137_at | WBGene00009796 | F46G10.1 | unknown function – contains potassium channel tetramerization domain | -2.2 | -1.7 | |
| 192644_at | WBGene00002010 | hsp-6 | heat shock 70 protein | Stress | -1.8 | -1.8 |
| 184978_at | WBGene00003130 | map-2 | methionine aminopeptidase | Anti-apoptosis | -1.8 | -1.6 |
| 191082_at | WBGene00009165 | F26E4.12 | glutathione peroxidase | Redox | -1.6 | -1.9 |
| 183671_at | WBGene00019058 | F58F9.4 | unknown function – contains DUF272 domain | -1.7 | -1.5 | |
| 185811_at | WBGene00022194 | Y71H2B.4 | unknown function | -1.7 | -1.4 | |
| 178599_at | WBGene00004997 | spp-12 | saposin like protein family | Lipid metabolism | -1.1 | -1.2 |
| 193531_at | WBGene00001668 | gpa-6 | G protein alpha subunit involved in chemosensation | Sensory | 1.7 | 1.3 |
| 183021_at | WBGene00018615 | F48G7.4 | unknown function | 1.9 | 1.3 | |
| 186977_at | WBGene00014033 | ZK643.1 | arrestin like protein | Sensory | 1.9 | 1.6 |
| 175989_at | WBGene00017042 | D2007.2 | unknown function – contains MSP domain | Axon Guidance | 1.9 | 1.5 |
| 180587_at | WBGene00018288 | F41E6.7 | unknown function | 2.0 | 1.7 | |
| 176365_at | WBGene00022479 | fbxa-36 | F-box A protein | Ubiquitination | 2.4 | 1.4 |
| 193559_s_at | WBGene00003644 | nhr-54 | nuclear hormone receptor-54 | Transcription factor | 1.3 | 1.5 |
| 185495_at | WBGene00016094 | C25E10.4 | predicted transporter/transmembrane protein | Membrane channel | 1.6 | 1.4 |
| 193861_at | WBGene00006614 | trp-1 | transient receptor potential ion channel involved in sensory transduction | Sensory, membrane channel | 1.5 | 1.5 |
| 188133_at | WBGene00004226 | ptr-12 | patch related family | Sterol trafficking | 1.7 | 1.7 |
| 179248_at | WBGene00008693 | F11C1.4 | unknown function | 1.6 | 1.4 | |
| 184849_at | WBGene00020869 | T28A11.2 | unknown function – contains DUF19 domains | 1.8 | 1.5 | |
| 179132_at | WBGene00007854 | C31H5.1 | alpha/beta hydrolase of unknown function | Sensory | 1.4 | 1.8 |
| 178276_at | WBGene00007421 | C07H4.1 | unknown function | 1.7 | 1.4 | |
| 175147_at | WBGene00000969 | dhs-5 | dehydrogenase, short chain – possible steroid dehydrogenase | Detoxification | 1.2 | 1.8 |
| 174374_s_at | WBGene00018576 | F47G3.1 | unknown function | Sensory | 1.4 | 1.9 |
| 192917_s_at | WBGene00008547 | F07A11.4 | ubiquitin carboxyl-terminal hydrolase | Ubiquitination | 1.6 | 2.1 |
| 192646_at | WBGene00010396 | H13N06.2 | unknown function – contains VWA invertebrate integrin domain | 1.5 | 1.5 | |
| 191570_s_at | WBGene00009717 | dep-1 | class III receptor protein tyrosine phosphatase (R-PTP) | Signaling | 1.6 | 1.8 |
| 193155_s_at | WBGene00009781 | F46C5.6 | unknown function – contains 2 HEAT repeat domains | 1.8 | 1.9 | |
| 187505_at | WBGene00015139 | B0310.3 | unknown function | 1.2 | 2.0 | |
| 179197_s_at | WBGene00007672 | fbxa-136 | F-box A protein | Ubiquitination | 1.6 | 2.1 |
| 189341_s_at | WBGene00013875 | ZC376.3 | b-type carboxylesterase | Detoxification | 1.7 | 2.1 |
| 185117_at | WBGene00016657 | C44E12.1 | N-acyl-L-amino-acid amidohydrolase | Amino acid metabolism | 1.7 | 2.5 |
| 193763_at | WBGene00009854 | clec-31 | unknown function – contains 2 C-type lectin domains | 2.1 | 1.5 | |
| 186028_at | WBGene00015371 | C03A7.13 | UDP-glucuronosyl/glucosyl transferase | Detoxification | 2.1 | 1.6 |
| 177226_s_at | WBGene00022016 | Y61A9LA.4 | unknown function | 2.4 | 1.5 | |
| 189292_at | WBGene00019438 | cyp-25A6 | cytochrome P450 | Detoxification | 2.4 | 1.7 |
| 191150_at | WBGene00006486 | tag-140 | predicted Zn transporter | Membrane channel | 1.7 | 1.7 |
| 178686_s_at | WBGene00013885 | ZC412.4 | unknown function | 1.7 | 1.6 | |
| 181726_at | WBGene00002140 | inx-18 | innexin – invertebrate gap junction protein | Membrane channel | 1.8 | 1.8 |
| 188880_at | WBGene00007924 | C34C12.5 | Ras suppressor protein | Cell Adhesion | 1.9 | 1.8 |
| 188007_at | WBGene00006984 | zig-7 | 2(Zwei) IG-domain protein | Cell Adhesion | 1.7 | 1.8 |
| 193031_at | WBGene00011556 | T07A5.3 | sugar phosphate permease | Membrane channel | 2.1 | 1.5 |
| 191623_at | WBGene00020182 | ugt-53 | UDP-glucuronosyl/glucosyl transferase | Detoxification | 2.3 | 1.8 |
| 186581_at | WBGene00013819 | Y116F11A.6 | unknown function – contains caspase recruitment domain | Apoptosis/Cell Death | 2.5 | 1.7 |
| 188459_s_at | WBGene00000779 | cpn-3 | Calponin | Actin related | 2.0 | 2.1 |
| 177598_at | WBGene00012034 | T26C5.4 | unknown function | 2.1 | 2.1 | |
| 176229_at | WBGene00018367 | F42H10.3 | unknown function – contains Nebulin repeat domain | Actin related, Cell Adhesion | 2.1 | 2.0 |
| 193302_at | WBGene00010675 | K08E7.8 | unknown function – contain leucine rich repeat domain | Apoptosis/Cell Death | 2.0 | 2.1 |
| 183894_at | WBGene00015889 | C17C3.3 | acyl co-A thioesterase | Lipid metabolism | 3.1 | 2.4 |
| 189169_s_at | WBGene00001480 | fmo-5 | flavin-containing monooxygenase | Detoxification | 3.1 | 1.6 |
| 175285_at | WBGene00018747 | F53C3.3 | unknown function – contains CX module | 3.3 | 2.1 | |
| 188099_s_at | WBGene00006582 | tmd-2 | Tropomodulin | Actin related | 2.8 | 2.4 |
| 173824_at | WBGene00022788 | ZK682.2 | sugar phosphate permease | Membrane channel | 2.7 | 2.5 |
| 190692_at | WBGene00012322 | W07A12.4 | unknown function – contains btb/poz domain | Ubiquitination | 2.4 | 2.3 |
| 189557_at | WBGene00015062 | trx-1 | Thioredoxin | Redox | 3.2 | 1.7 |
| 193582_at | WBGene00003629 | nhr-38 | nuclear hormone receptor involved in thermosensation | Sensory | 2.4 | 2.1 |
| 178886_at | WBGene00009328 | F32D8.3 | unknown function – contains trypsin Inhibitor like cysteine rich domain | 3.1 | 2.4 | |
| 190432_at | WBGene00001608 | R07B1.8 | unknown function – contains GTP binding domain | 1.9 | 2.2 | |
| 190957_at | WBGene00001763 | gst-15 | glutathione S-transferase | Redox | 2.2 | 2.1 |
| 188131_s_at | WBGene00006318 | sup-9 | TWK potassium channel | Membrane channel | 2.4 | 1.9 |
| 184319_at | WBGene00000780 | cpn-4 | Calponin | Actin related | 2.5 | 2.1 |
| 190211_at | WBGene00008746 | dpy-30 | adenylate kinase like | 2.5 | 2.5 | |
| 177839_s_at | WBGene00013481 | Y69H2.3 | unknown function – contains trypsin inhibitor like cysteine rich domain | 2.3 | 2.3 | |
| 192432_at | WBGene00008028 | scl-6 | defense-related protein containing SCP domain | 2.4 | 2.7 | |
| 191916_at | WBGene00015559 | C06G4.5 | G-protein coupled receptor | 2.5 | 2.6 | |
| 190719_at | WBGene00017332 | ugt-37 | UDP-glucuronosyl/glucosyl transferase | Detoxification | 1.6 | 4.2 |
| 192997_s_at | WBGene00018832 | pat-2 | vitronectin receptor, alpha subunit | Actin related, Cell Adhesion | 1.8 | 3.0 |
| 172944_s_at | WBGene00018720 | F53A3.1 | unknown function | 2.9 | 3.7 | |
| 193210_s_at | WBGene00006794 | unc-60c | actin depolymerizing factor | Actin related | 2.5 | 2.6 |
| 187747_at | WBGene00006814 | unc-82 | serine/threonine protein kinase required for thick filament organization | 2.2 | 2.9 | |
| 173480_s_at | WBGene00021167 | cyp-32B1 | cytochrome P450 | Detoxification | 2.5 | 2.2 |
| 173698_s_at | WBGene00008499 | cyp-37A1 | cytochrome P450 | Detoxification | 3.0 | 2.3 |
| 186562_s_at | WBGene00012875 | Y45F10B.13 | unknown function | 2.8 | 3.3 | |
| 179847_s_at | WBGene00018720 | F53A3.1 | unknown function | 2.3 | 2.5 | |
| 193108_s_at | WBGene00003485 | mua-6 (ifa-2) | intermediate filament protein | Cell Adhesion | 3.7 | 3.9 |
| 191689_s_at | WBGene00007422 | ugt-17 | UDP-glucuronosyl/glucosyl transferase | Detoxification | 4.1 | 4.3 |
| 183314_at | WBGene00016210 | C29F5.1 | unknown function | 4.7 | 5.5 | |
| 178198_at | WBGene00011251 | glb-22 | unknown function – contains globin domain | 4.7 | 3.3 | |
| 186720_at | WBGene00020881 | T28A11.19 | predicted secreted cysteine rich protein | 4.3 | 3.7 | |
| 183178_at | WBGene00020690 | T22E5.1 | unknown function | Actin related | 5.2 | 3.5 |
| 190445_at | WBGene00008490 | F01D4.8 | cysteine synthase/cystathionine beta-synthase family | Redox | 6.6 | 1.8 |
| 185116_s_at | WBGene00019934 | R07C12.4 | unknown function | 5.5 | 3.1 | |
| 177733_at | WBGene00005654 | srr-3 | serpentine receptor, class R | Sensory | 7.5 | 2.9 |
| 181201_at | WBGene00018479 | F45F2.6 | otopetrin like transmembrane protein | Sensory | 6.7 | 5.1 |
| 189633_at | WBGene00015045 | cyp-34A10 | cytochrome P450 | Detoxification | 2.2 | 21.2 |
a- Gene names and descriptions were derived from WormBase, release WS189 [46].
b- WormBase gene identifier.
c- Gene expression fold change values for dichlorvos SVM predicted high concentration
d- Gene expression fold change values for fenamiphos high concentration