Table 3.
Proteomic changes upon organophosphorus pesticide intoxication
| Genomic Resultsf | ||||||||
| Genea | Proteinsb | Description |
Fold Changec |
Quant Fractsd | Total Fractse | MH | DH | FH |
| C29F5.1 | NP_495267.1 | unknown function | OP only | 0 | 1 | -1.2 | 5.6 | 5.5 |
| C42D4.1 | NP_501136.1 | unknown function – predicted alpha-helical protein | OP only | 0 | 2 | 14.8 | 5.4 | 6.7 |
| C42D4.3 | NP_501132.1 | unknown function – contains fibronectin domain | OP only | 0 | 2 | 4.9 | 4.3 | 5.0 |
| cul-3 | NP_503151.1 | Cullin | OP only | 0 | 1 | -1.3 | -1.4 | -1.5 |
| E04F6.5 | NP_001022062.1 NP_001022063.1 | Very-long-chain acyl-CoA dehydrogenase | OP only | 0 | 1 | 1.1 | 1.0 | -1.2 |
| K03E5.2 | NP_001021535.1 NP_001021536.1 NP_001040674.1 | predicted calponin | OP only | 0 | 2 | -1.2 | 3.0 | 2.9 |
| T28F4.5 | NP_492102.1 | homolog of Death Associated Protein 1 | OP only | 0 | 1 | 2.6 | 1.7 | 1.4 |
| Y57G11A.3 | NP_502756.1 | unknown function – contains LIM domain | OP only | 1 | 1 | 1.6 | 4.4 | 6.0 |
| gei-7 | NP_001021367.1 NP_503306.1 | isocitrate lyase/malate synthase | 3.0 | 4 | 4 | 3.3 | 4.5 | 3.8 |
| C32D5.8 | NP_001022003.1 NP_001022004.1 | unknown function – contains thioredoxin domain | 2.9 | 1 | 1 | 2.7 | 4.3 | 3.9 |
| T19B10.2 | NP_505848.1 | unknown function | 2.3 | 5 | 6 | 9.3 | 4.3 | 4.8 |
| C06A8.3 | NP_495640.1 | homolog of OV-17 hypodermal antigen | 2.2 | 4 | 6 | 2.4 | 2.1 | 2.2 |
| nex-1 | NP_498109.1 | Annexin | 2.2 | 3 | 4 | 2.2 | 2.8 | 2.3 |
| ifb-1 | NP_495136.1 NP_495137.1 | intermediate filament, B | 1.9 | 3 | 4 | 1.1 | 1.5 | 1.5 |
| sap-1 | NP_494763.1 | U2-associated snRNP A' protein | 1.8 | 1 | 1 | -1.3 | -1.3 | -1.2 |
| ZK909.3 | NP_493608.2 | guanosine polyphosphate pyrophosphohydrolase/synthase | 1.8 | 1 | 1 | 3.7 | 2.5 | 2.5 |
| pfn-3 | NP_508205.1 | Profiling | 1.7 | 2 | 2 | 1.2 | 3.8 | 4.3 |
| H34C03.2 | NP_501035.1 | ubiquitin C-terminal hydrolase | 1.7 | 1 | 1 | -1.2 | -1.4 | -1.3 |
| spp-14 | NP_001041271.1 | saposin like protein family | 1.6 | 1 | 1 | |||
| unc-60c | NP_503427.2 | cofilin – actin depolymerizing factor | 1.6 | 2 | 2 | 1.9 | 1.8 | 1.8 |
| tag-273a | NP_001023516.1 | unknown function – contains LIM domain | 1.5 | 1 | 1 | -1.2 | 2.0 | 3.5 |
| unc-87 | NP_001021092.1 NP_001021093.1 NP_001021094.1 | myofilament associated protein | 1.5 | 4 | 6 | -2.2 | 1.2 | 1.6 |
| F22F7.1 | NP_503577.1 NP_872194.1 | uncharacterized membrane protein | -1.6 | 1 | 2 | -2.5 | -4.3 | -4.4 |
| ttr-16 | NP_502060.1 | transthyretin like family | -1.6 | 1 | 1 | 1.1 | -1.0 | 1.0 |
| dct-16 | NP_507944.1 | unknown function – daf-16 regulated | -1.7 | 2 | 4 | -4.6 | -4.8 | -5.1 |
| dsc-4 | NP_499903.3 | microsomal triglyceride transfer protein, large subunit | -1.7 | 1 | 3 | -1.3 | -2.4 | -2.0 |
| pmt-1 | NP_494990.2 NP_494991.1 NP_871997.1 | phosphoethanolamine N-methyltransferase | -1.7 | 2 | 3 | 1.9 | 1.5 | 1.3 |
| ZK1127.10 | NP_495449.1 | cystathionine gamma-lyase | -1.8 | 1 | 3 | -1.3 | -1.7 | -1.9 |
| asp-1 | NP_741677.1 | aspartyl protease | -1.9 | 3 | 4 | 1.2 | -1.3 | -1.2 |
| pod-2 | NP_001022400.1 NP_001022401.1 | acetyl-CoA carboxylase domain | -2.0 | 1 | 6 | 2.2 | 1.0 | -1.2 |
| asp-5 | NP_505135.1 | aspartyl protease | -2.2 | 2 | 2 | -1.0 | -1.3 | -1.1 |
| dct-18 | NP_496755.1 | unknown function – daf-16 regulated | -2.4 | 3 | 3 | -2.2 | -1.9 | -1.9 |
| F48E3.3 | NP_509268.1 | UDP-glucose:glycoprotein glucosyltransferase domain | Cont only | 0 | 2 | 1.2 | -1.2 | -1.0 |
| ifg-1 | NP_001022259.1 NP_001022260.1 | initiation factor 4G | Cont only | 0 | 2 | 1.4 | 1.0 | 1.1 |
a- Gene names and descriptions were derived from WormBase, release WS189 [46].
b- NCBI protein accession number
c- Protein fold change values for OP exposure. Proteins identified as "OP only" or "Cont only" were identified in at least 4 replicates of the OP-exposed or control samples and in no replicates of the other condition.
d- Number of fractions in which quantitative comparisons were made
e- Number of fractions in which protein was identified
f- Gene expression fold change values for mefloquine (MH), dichlorvos (DH), and fenamiphos (FH) high concentration exposure. Gene expression levels for H34C03.2 were below signal to noise threshold.